You've done your homework on Celexa. That's good to see. Most people don't. Unlike the negative experience mentioned previously, I have been doing quite well on Celexa. I've been on Celexa for over a year. I started out doing very well at 20mg. I wasn't irritated by the little things and driving was a much more pleasant experience. I'm not a road rager but I drive quite a bit and there's plenty of things on the California roadways to anger even the most calm driver. I did experience some sedation and delayed ejaculation after my MD increased the dosage to 40mg but my symptoms didn't improve. My MD thought since I did so well at 20mg, maybe 40mg would be even better. Went back to 20mg and that's where I've been ever since and without ANY side effects. If you get any nausea, it's common with any SSRI so ride it out. There are also seratonin receptors in the gut so your body needs to adjust to the increased amount of seratonin floating around. Any nausea should be mild and will subside after about a week or two. You can offset any nausea by taking it with a meal. It's important to CONTINUE taking Celexa for at least 4 to 6 weeks to get the full effect before deciding it's not working for you. I know it might be hard to deal with that if you're feeling any side effects at all without feeling any better, but that's how SSRIs work. Also remember that SSRIs are a preventative treatment. Don't stop taking them if you start feeling better. You WILL relapse. Depression is often due to a lack of seratonin floating free in the synapse of the brain. SSRIs are not like an antibiotic. You don't stop taking them after they run out and you're feeling better. It takes at least 6 months of continuous treatment to make you better and very often, as in my case, your body just does not produce enough seratonin on its own so you might have to be on an SSRI for life or until they can figure out how to correct it permanently.The good news is Celexa has a better side effect profile than the other SSRIs and will often work faster than the other SSRIs because it reaches steady state faster than the others. For example, Prozac can take as long as 8 weeks to attain steady state. Anyone reading this should take note, if your MD prescribed an SSRI for you, you have to give it a chance to work. Good Luck