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FYIAnn Clin Biochem. 2004 May;41(Pt 3):230-2. Related Articles, Links Faecal calprotectin: a new marker for Crohn's disease?Wassell J, Dolwani S, Metzner M, Losty H, Hawthorne A.Department of Medical Biochemistry, Southmead Hospital, Westbury on Trym, Bristol BS10 5NB, UK. julie.wassell###north-bristol.swest.nhs.ukBACKGROUND: Gastroenterologists are often hampered by the lack of a reliable, non-invasive index of bowel inflammation when establishing a differential diagnosis for patients presenting with chronic diarrhoea. Investigations aim to distinguish between inflammatory bowel disease (IBD) (e.g. Crohn's disease, ulcerative colitis) and irritable bowel syndrome (IBS). As an acute phase protein, faecal calprotectin measurement may be useful in this context. METHODS: A new ELISA-based assay for calprotectin was evaluated. The ability of calprotectin to distinguish between patients with IBS and Crohn's disease was studied. RESULTS: The assay showed adequate inter- and intra-batch imprecision and was suitable for routine use in the laboratory. Calprotectin concentration was significantly greater in patients with Crohn's disease compared with controls (n = 25, P 0.001) and patients with IBS (n = 25, P 0.001). CONCLUSION: A single calprotectin measurement may aid gastroenterologists in the differential diagnosis of Crohn's disease and IBS. Its use could decrease the number of invasive or radiological investigations undertaken in the latter group of patients.PMID: 15117438
 

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Funny you should post this, Eric, I just ordered a test through Great Smokies Diagnostic Laboratory(via crohns.net) that includes the test mentioned above, as well as analyses for dysbiosis(low beneficial bacteria) and possible parasites."Great Smokies Gut Immunology""Evaluates immunological imbalance specific to gastrointestinal tract inflammatory disease activity. Calprotectin is effective in distinguishing IBD, IBS and gastrointestinal neoplasm. Eosinophil Protien X offers increased sensitivity for evaluating inflammatory disease activity and for predicting relapses in patients with IBD. Individual Components: Calprotectin Eosinophil ProteinPrice:$170.00 http://www.crohns.net/Merchant2/merchant.m...Product_Count=9 The "gut immunology" test is included in what I ordered: Great Smokies Comprehensive Digestive Stool Analysis (CDSA) & Parasitology 2.0 http://www.crohns.net/Merchant2/merchant.m...Product_Count=1
 

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Funny you should post this, Eric, I just ordered a test through Great Smokies Diagnostic Laboratory(via crohns.net) that includes the test mentioned above, as well as analyses for dysbiosis(low beneficial bacteria) and possible parasites."Great Smokies Gut Immunology""Evaluates immunological imbalance specific to gastrointestinal tract inflammatory disease activity. Calprotectin is effective in distinguishing IBD, IBS and gastrointestinal neoplasm. Eosinophil Protien X offers increased sensitivity for evaluating inflammatory disease activity and for predicting relapses in patients with IBD. Individual Components: Calprotectin Eosinophil ProteinPrice:$170.00 http://www.crohns.net/Merchant2/merchant.m...Product_Count=9 The "gut immunology" test is included in what I ordered: Great Smokies Comprehensive Digestive Stool Analysis (CDSA) & Parasitology 2.0 http://www.crohns.net/Merchant2/merchant.m...Product_Count=1
 

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In case someone's interested, here's more info on the test I ordered:"(CDSA) & Parasitology 2.0 uses advanced GI biotechnology to evaluate digestion, absorption, pancreatic function, and inflammation, in addition to bacterial balance, yeast, and parasite infection. This profile features exclusive new markers for assessing irritable bowel syndrome, sub-mucosal inflammation, colorectal cancer risk, pancreatic insufficiency, and occult infection." http://www.gsdl.com/assessments/findsystems/gastro.html
 

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In case someone's interested, here's more info on the test I ordered:"(CDSA) & Parasitology 2.0 uses advanced GI biotechnology to evaluate digestion, absorption, pancreatic function, and inflammation, in addition to bacterial balance, yeast, and parasite infection. This profile features exclusive new markers for assessing irritable bowel syndrome, sub-mucosal inflammation, colorectal cancer risk, pancreatic insufficiency, and occult infection." http://www.gsdl.com/assessments/findsystems/gastro.html
 
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