Hi everyone;I am new to this site, and I had two feelings when I joined. One, I felt relief that there were so many people like me. And, two, sadness that so many people are like me!!I have had IBS-D for about 8 years now. I am a 42- year old female, happily married, and have a 15-year old daughter.I have been on several different antidepressants. The very first one I tried was Zoloft, in combination with Bentyl, and was amazed at how well that worked. I felt almost normal. Unfortunately, as with all things, good things must end! Currently, I am on Cymbalta 60mg. We went to a 90mg dose, and that definitely worked better, but the nausea I experienced with it everyday made me cut back to the 60. I take Percocet at night, with close supervision from my Dr. The Percocet is a definite help, but this past week, I seem to have slipped back into my 5-8x a day bathroom trips. What a drag! It definitely gets frustrating. I realized when I had herniated a disk in my back and was taking the Percocet for pain, that going to the bathroom was a little more normal and brought it up to my Dr. Thankfully, she is the type that believes in doing what it takes to get a person's life back. Just wanted to give a little bit of history of myself and hope that I can offer something to anyone else on this site and find comfort and suggestions for myself.