I am a newbie and have suffered from IBS-D for about four years now. I just recently started seeking help (Stupid). I have tried Bentyl and Clidinium. Neither seem to help. I have tried taking them on a regular schedule and only as needed, it doesn't work either way. One thing I can say is that I should probably be a majority shareholder in Imodium by now. My question is that I am worried about possible long term effects of taking Imodium regularly, does anyone have any info on this. Also, has anyone heard of using the Amino Acid "L-Glutamine" regularly. I have read that it has tremendously helped a lot of people. Any info would be wonderful!!!!!