Hi Debiniowa,I have IBS-D. It's a pain isn't it?I'm very new at this bullitin board but there is loads of info you can get just by reading the other posts. My experience with IBS-D has gone on for over 10 years. I have been on so many meds I can't even remember all of them. I do remember that before Lotronex, I was taking Questran every night and although it is no Lotronex, it did help.IBS is something you have to experiment with and learn what works best for you as everyone is different. I have trouble with a high fiber diet. It seems to make my D worse but that doesn't mean it will yours.Hang in there