Have you taken any antidepressants? If not I'd suggest you talk to your doctor. I'm currently on Effexor XR 75mgs for 5 months now and it has played an important role in getting me out of my depression. My IBS D is now under control. I also take Caltrate + for the D,Aloe vera to control the irritation resulting from my flare-ups and beano & phayzme for the gas. I also stay away from foods that can trigger my flare-ups. You have to keep experimenting until you find the right combination that works best for you.