Was reading: "There is only a single medication that has been approved for diarrhea predominant IBS"Am wondering why loperamide hasn't been approved for diarrhoea predominant IBS - does anyone know the reason for this?
Because it was approved a long time ago for acute diarrhea and there isn't any financial incentive to spend millions of dollars to prove to the FDA it works for other things.About the only time a drug gets approved for off-label use is if the timing works out and they can extend their patent protection and make the money back.It is rare any drug gets approved for all the other things they find the drug is good for. Lack of approval doesn't mean you can't prescribe it (or take it over the counter) or there never were any studies showing it can be safe and effective for a dozen other diseases besides the one it was initially developed for. Just it costs a lot less for someone to show it may be a good treatment rather than all the tests needed for the FDA to put their stamp on it.There are a few studies with Imodium in IBSers and that is more than enough for most patients and doctors. Very few people restrict their drug use to only the exact diseases the FDA approval was filed for.
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