I was dx last summer with CVID (Common Variable Immunoodeficiency). GI problems are common in people with this illness, and since the diagnosis I have naturally been wondering what the relationship of the disease is to my IBS. I have a bit of an unusual situation with the CVID - although my immunoglobulin levels are dangerously low, I have so far been asymptomatic. My immunologist is amazed - normally, people with such low levels are constantly struggling with serious, sometimes life-threatening, infections. I have had no notable infections, and the findings were made by accident when I was undergoing some other testing. Even though I have had no symptoms, the decision was made to treat it (treatment being IV infusions of IG). So far, I have not been able to tolerate the IG replacement therapy (causes aseptic meningitis - no fun!). I have not yet tried the subcutaneous route as far as administering the IG - after bad experiences with the infusions, I am a little gun shy. So the question is really to treat or not to treat, and that question is still up in the air with my health care providers and me.I am curious to know if anyone else here has CVID, and what role you think it playsin your GI problems. Did/does IG replacement therapy help? Any other advice? My main problems are gas, bloating/abdominal distention, cramping, and periodic bouts of D. I believe I have pretty much ruled out dietary triggers, prophylactic Beano every time I eat seems to help the most.