I only have a month's supply of Lotronex left, so I went to my doctor (i have had IBS-D for 7 years). He recommended I take Pamine, because it has very few side effects. I also have a lot of anxiety associated with IBS. He suggested I go see a separate doctor to treat the anxiety. He said perhaps I should try Xanax. Does anyone else have these symptoms? Is anyone else on these meds? Any information would be appreciated. Thanks.