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Study Shows Depression Drug Helps IBS ImmuneSupport.com05-12-2004 Drug for depression helps irritable bowel syndrome, according to Pittsburgh study Participants on high-fiber diet also showed improvement Paroxetine, a drug commonly used to treat depression, can improve symptoms in people with irritable bowel syndrome (IBS), according to a study in the May issue of the American Journal of Gastroenterology. In a randomized double-blind, placebo-controlled study, researchers at the University of Pittsburgh School of Medicine found that the drug relieved some symptoms of IBS and improved the well-being of people with IBS. "This study points out the benefits of this drug as a potential new and improved treatment for IBS, a disease that is very difficult for physicians to manage," said George Arnold, M.D., F.A.C.P., clinical professor of medicine at the University of Pittsburgh School of Medicine and principal investigator in the study. IBS is a chronic gastrointestinal disorder that affects 14-24 percent of women and 5-19 percent of men in western populations and is characterized by abdominal pain, altered bowel habits and abdominal bloating. It generally has been treated with high-fiber diet, drugs or both. The study found that the percentage of participants experiencing an improvement in overall well-being was significantly greater (63.3 percent) in the paroxetine group than the placebo group (26.3 percent). The percentage of participants experiencing an improvement in bowel movements was significantly greater in the paroxetine recipients (58.6 percent) than the placebo recipients (32.4 percent). There was a significant improvement in food avoidance and work function for those on paroxetine. There was no significant improvement in abdominal pain or bloating between the paroxetine and placebo groups. "This study showed that in absence of depression, paroxetine helped irritable bowel syndrome," said Dr. Arnold. "This is a medicine that has been in use for some years and is safe with no long term side effects, which is a problem with current medications for IBS." The effectiveness of paroxetine, a selective serotonin reuptake inhibitor (SSRI), has been reported in case reports but not in controlled studies. SSRIs are considered first line treatments in psychiatric illnesses such as major depression and generalized anxiety disorder, which are found in 50 to 90 percent of patients with IBS, according to Dr. Arnold, who is a gastroenterologist at the University of Pittsburgh Medical Center's (UPMC) Shadyside Hospital. The two-part clinical study enrolled a total of 110 participants with IBS. Group one consisted of 98 participants who at enrollment were consuming a low-fiber or average-fiber diet, who were then put on a high-fiber diet. In this group, 26 percent reported an overall improvement in well-being. Abdominal pain and bloating decreased in 22 percent and 26 percent of participants respectively. Group two consisted of 12 participants who at enrollment were already consuming a high-fiber diet plus the 69 participants from group one who reported an inadequate response to the high-fiber diet. Group two participants continued to consume their high-fiber diet throughout the study and were randomized to receive a 12-week course of either paroxetine or a placebo. All participants began with a dosage of paroxetine of 10 mg/day. Participants who experienced improvement in their condition were instructed to continue at the same dosage while those who experienced no improvements were instructed to increase their dosage. Because SSRIs have a well-recognized effect on depression, the researchers also performed a separate analysis of participants and showed that the improvement in well-being held true for non-depressed patients taking paroxetine. Also participating in the study were Gary Tabas, M.D., Mary Beaves, R.N., Jiping Wang, M.D., Paul Friday, Ph.D. and Houssam Mardini, M.D. The study was funded by the Competitive Research Fund of the Shadyside Hospital Foundation of Pittsburgh. Source: EurekAlert.org (this is a press release).
 

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The better treatment available when high fibers fails?
 

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Discussion Starter · #5 ·
The better treatment available when high fibers fails?
 

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"Based on the results of the most recent studies, both tricyclic antidepressants and SSRIs may improve patient satisfaction or quality-of-life without relieving most of the primary gastrointestinal symptoms. This suggests that antidepressant therapy represents at best only a "band-aid" approach to management. " http://www.ncbi.nlm.nih.gov/entrez/query.f...t_uids=15128361 _________________So in other words, SSRI's make people feel better about life, but it doesn't change their primary gut problems. And the above reference puts a positive spin on side-effects of Paxil, but here's what they are:Less commonAgitation; chest congestion; chest pain; chills; cold sweats; confusion; difficulty breathing; dizziness, faintness, or lightheadedness when getting up from a lying or sitting position; fast, pounding, or irregular heartbeat or pulse; muscle pain or weakness; skin rash. RareAbsence of or decrease in body movements; bigger, dilated, or enlarged pupils [black part of eye]; difficulty in speaking; inability to move eyes; incomplete, sudden, or unusual body or facial movements; increased sensitivity of eyes to light; low blood sodium (confusion, convulsions [seizures], drowsiness, dryness of mouth, increased thirst, lack of energy); red or purple patches on skin; serotonin syndrome (confusion, diarrhea, fever, poor coordination, restlessness, shivering, sweating, talking and acting with excitement you cannot control, trembling or shaking, twitching); talking, feeling, and acting with excitement and activity you cannot control. Incidence not determinedBack, leg, or stomach pains; bleeding gums; blindness; blistering, peeling, loosening of skin; bloated, full feeling; bloody or black, tarry stools; bloody urine; blue-yellow color blindness; blurred vision; coma; constipation; cough or hoarseness; dark urine; decreased frequency or amount of urine; decreased vision; depression; difficulty opening the mouth; difficulty swallowing; electric shock sensations; epileptic seizure that will not stop; excessive muscle tone; eye pain; fainting; fixed position of eye; fluid-filled skin blisters; general body swelling; general feeling of tiredness or weakness; headache; high fever; hives; inability to move arms and legs; inability to sit still; increased blood pressure; increased sweating; increased thirst; incremental or ratchet-like movement of muscle; indigestion; itching skin; joint pain; lab results that show problems with liver; light-colored stools; lockjaw; loss of appetite; loss of bladder control; low blood pressure; lower back or side pain; muscle spasm, especially of neck and back; muscle tension or tightness; nausea; need to keep moving; nosebleeds; painful knees and ankles; painful or difficult urination; painful or prolonged erection of the *****; pale skin; puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; raised red swellings on the skin, the buttocks, legs, or ankles; red irritated eyes; rigid muscles; seizure or coma late in pregnancy; sensitivity to the sun; skin redness or soreness; skin sores, welts or blisters; skin thinness; sore throat; sores, ulcers, or white spots on lips or in mouth; swelling of breasts; swollen or painful glands; shortness of breath; slow heart rate; slow movement; slow reflexes; spasms of throat; stiff muscles; stomach pain; sudden numbness and weakness in the arms and legs; swelling of face, fingers, lower legs; tightness in chest; unexpected or excess milk flow from breasts; unusual bleeding or bruising; unusual or decreased blood cell production; unusual tiredness or weakness; vomiting; weight gain; wheezing; yellowing of the eyes or skin.More commonAcid or sour stomach; belching; decreased appetite; decreased sexual ability or desire; excess air or gas in stomach or intestines; heartburn; nervousness; pain or tenderness around eyes and cheekbones; passing gas; problems in urinating; runny or stuffy nose; sexual problems, especially ejaculatory disturbances; sleepiness or unusual drowsiness; stomach discomfort, upset, or pain; sweating; trauma; trembling or shaking; trouble in sleeping. Less commonAbnormal dreams; anxiety; bladder pain; body aches or pain; change in sense of taste; changes in vision; cloudy urine; confusion; congestion; difficulty in focusing eyes; difficulty in moving; discouragement, feeling sad or empty; drugged feeling; dryness of throat; excessive muscle tone; fainting or loss of consciousness; fast or irregular breathing; feeling of unreality; feeling of warmth or heat; flushing or redness of skin, especially on face and neck; frequent urge to urinate; headache, severe and throbbing; heavy bleeding; increase in body movements; increased appetite; irritability; itching, pain, redness, or swelling of eye or eyelid; itching of the vagina or genital area; lack of emotion; loss of interest or pleasure; loss of memory; lump in throat; menstrual changes; menstrual pain or cramps; muscle twitching or jerking; pain during sexual intercourse; problems with memory; problems with tooth; rhythmic movement of muscles; sense of detachment from self or body; severe sunburn; slow heartbeat; sneezing; thick, white vaginal discharge with no odor or with a mild odor; tightness in throat; tingling, burning, or prickling sensations; trouble concentrating; voice changes; watering of eyes; weight loss; yawn. After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this period of time check with your doctor if you notice any of the following side effects:Abnormal dreams; agitation, confusion, or restlessness; burning, crawling, itching, numbness, prickling, "pins and needles" , or tingling feelings; diarrhea; dizziness or light-headedness; electric shock sensations; fear; headache; increased sweating; muscle pain; nausea or vomiting; nervousness; runny nose; trembling or shaking; trouble in sleeping; unusual tiredness or weakness; vision changes. Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor. http://www.mayoclinic.com/invoke.cfm?objec...9A5A2A3115076DA _____________________"It must be emphasized that a simple but comprehensive nonpharmacologic management program is most likely to succeed in practice in terms of achieving the best outcomes in IBS.""Drugs should generally remain second-line in IBS until agents with better efficacy and established safety profiles become available." http://www.medscape.com/viewprogram/1893_pnt In other words, the people who succeed at treating their IBS are those who treat the condition, without dangerous drugs.You treat the disease, not the symptoms._________________Sorry, but pharmaceutical companies really tick me off! Talissa
 

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"Based on the results of the most recent studies, both tricyclic antidepressants and SSRIs may improve patient satisfaction or quality-of-life without relieving most of the primary gastrointestinal symptoms. This suggests that antidepressant therapy represents at best only a "band-aid" approach to management. " http://www.ncbi.nlm.nih.gov/entrez/query.f...t_uids=15128361 _________________So in other words, SSRI's make people feel better about life, but it doesn't change their primary gut problems. And the above reference puts a positive spin on side-effects of Paxil, but here's what they are:Less commonAgitation; chest congestion; chest pain; chills; cold sweats; confusion; difficulty breathing; dizziness, faintness, or lightheadedness when getting up from a lying or sitting position; fast, pounding, or irregular heartbeat or pulse; muscle pain or weakness; skin rash. RareAbsence of or decrease in body movements; bigger, dilated, or enlarged pupils [black part of eye]; difficulty in speaking; inability to move eyes; incomplete, sudden, or unusual body or facial movements; increased sensitivity of eyes to light; low blood sodium (confusion, convulsions [seizures], drowsiness, dryness of mouth, increased thirst, lack of energy); red or purple patches on skin; serotonin syndrome (confusion, diarrhea, fever, poor coordination, restlessness, shivering, sweating, talking and acting with excitement you cannot control, trembling or shaking, twitching); talking, feeling, and acting with excitement and activity you cannot control. Incidence not determinedBack, leg, or stomach pains; bleeding gums; blindness; blistering, peeling, loosening of skin; bloated, full feeling; bloody or black, tarry stools; bloody urine; blue-yellow color blindness; blurred vision; coma; constipation; cough or hoarseness; dark urine; decreased frequency or amount of urine; decreased vision; depression; difficulty opening the mouth; difficulty swallowing; electric shock sensations; epileptic seizure that will not stop; excessive muscle tone; eye pain; fainting; fixed position of eye; fluid-filled skin blisters; general body swelling; general feeling of tiredness or weakness; headache; high fever; hives; inability to move arms and legs; inability to sit still; increased blood pressure; increased sweating; increased thirst; incremental or ratchet-like movement of muscle; indigestion; itching skin; joint pain; lab results that show problems with liver; light-colored stools; lockjaw; loss of appetite; loss of bladder control; low blood pressure; lower back or side pain; muscle spasm, especially of neck and back; muscle tension or tightness; nausea; need to keep moving; nosebleeds; painful knees and ankles; painful or difficult urination; painful or prolonged erection of the *****; pale skin; puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; raised red swellings on the skin, the buttocks, legs, or ankles; red irritated eyes; rigid muscles; seizure or coma late in pregnancy; sensitivity to the sun; skin redness or soreness; skin sores, welts or blisters; skin thinness; sore throat; sores, ulcers, or white spots on lips or in mouth; swelling of breasts; swollen or painful glands; shortness of breath; slow heart rate; slow movement; slow reflexes; spasms of throat; stiff muscles; stomach pain; sudden numbness and weakness in the arms and legs; swelling of face, fingers, lower legs; tightness in chest; unexpected or excess milk flow from breasts; unusual bleeding or bruising; unusual or decreased blood cell production; unusual tiredness or weakness; vomiting; weight gain; wheezing; yellowing of the eyes or skin.More commonAcid or sour stomach; belching; decreased appetite; decreased sexual ability or desire; excess air or gas in stomach or intestines; heartburn; nervousness; pain or tenderness around eyes and cheekbones; passing gas; problems in urinating; runny or stuffy nose; sexual problems, especially ejaculatory disturbances; sleepiness or unusual drowsiness; stomach discomfort, upset, or pain; sweating; trauma; trembling or shaking; trouble in sleeping. Less commonAbnormal dreams; anxiety; bladder pain; body aches or pain; change in sense of taste; changes in vision; cloudy urine; confusion; congestion; difficulty in focusing eyes; difficulty in moving; discouragement, feeling sad or empty; drugged feeling; dryness of throat; excessive muscle tone; fainting or loss of consciousness; fast or irregular breathing; feeling of unreality; feeling of warmth or heat; flushing or redness of skin, especially on face and neck; frequent urge to urinate; headache, severe and throbbing; heavy bleeding; increase in body movements; increased appetite; irritability; itching, pain, redness, or swelling of eye or eyelid; itching of the vagina or genital area; lack of emotion; loss of interest or pleasure; loss of memory; lump in throat; menstrual changes; menstrual pain or cramps; muscle twitching or jerking; pain during sexual intercourse; problems with memory; problems with tooth; rhythmic movement of muscles; sense of detachment from self or body; severe sunburn; slow heartbeat; sneezing; thick, white vaginal discharge with no odor or with a mild odor; tightness in throat; tingling, burning, or prickling sensations; trouble concentrating; voice changes; watering of eyes; weight loss; yawn. After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this period of time check with your doctor if you notice any of the following side effects:Abnormal dreams; agitation, confusion, or restlessness; burning, crawling, itching, numbness, prickling, "pins and needles" , or tingling feelings; diarrhea; dizziness or light-headedness; electric shock sensations; fear; headache; increased sweating; muscle pain; nausea or vomiting; nervousness; runny nose; trembling or shaking; trouble in sleeping; unusual tiredness or weakness; vision changes. Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor. http://www.mayoclinic.com/invoke.cfm?objec...9A5A2A3115076DA _____________________"It must be emphasized that a simple but comprehensive nonpharmacologic management program is most likely to succeed in practice in terms of achieving the best outcomes in IBS.""Drugs should generally remain second-line in IBS until agents with better efficacy and established safety profiles become available." http://www.medscape.com/viewprogram/1893_pnt In other words, the people who succeed at treating their IBS are those who treat the condition, without dangerous drugs.You treat the disease, not the symptoms._________________Sorry, but pharmaceutical companies really tick me off! Talissa
 

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paxil is one of the most dangerous of the SSRI's when it comes to stopping the medication. horrific symptoms are likely to occur. i have to agree that these drugs are masking the true problem.in the short term some people may benefit from the masking. the problem is that Western medical doctors don't really care about discovering the true cause. so long as they have the person on drugs with some degree of improvement they are satisfied.**************************** . increasing the level of serotonin as described has been shown in animal studies to be compensated for by a reduction of serotonin receptor sites (where the serotonin is received). These studies show that these receptor sites are lost permanently.13 This would indicate permanent brain damage.Prozac causes an alteration in normal brain functioning. This alteration could be irreversible. many of the individuals involved in the drug approval process have personal financial conflicts of interest and are therefore not objective. According to Fred A. Baughman, Jr., MD, a highly respected neurologist and expert in the field, theories of chemical imbalances causing problems are and have always been just theories. Further, no actual chemical imbalance in a "mentally ill" person's brain has ever been proven to exist, nor has a normal chemical balance ever been identified.2 .
 

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paxil is one of the most dangerous of the SSRI's when it comes to stopping the medication. horrific symptoms are likely to occur. i have to agree that these drugs are masking the true problem.in the short term some people may benefit from the masking. the problem is that Western medical doctors don't really care about discovering the true cause. so long as they have the person on drugs with some degree of improvement they are satisfied.**************************** . increasing the level of serotonin as described has been shown in animal studies to be compensated for by a reduction of serotonin receptor sites (where the serotonin is received). These studies show that these receptor sites are lost permanently.13 This would indicate permanent brain damage.Prozac causes an alteration in normal brain functioning. This alteration could be irreversible. many of the individuals involved in the drug approval process have personal financial conflicts of interest and are therefore not objective. According to Fred A. Baughman, Jr., MD, a highly respected neurologist and expert in the field, theories of chemical imbalances causing problems are and have always been just theories. Further, no actual chemical imbalance in a "mentally ill" person's brain has ever been proven to exist, nor has a normal chemical balance ever been identified.2 .
 

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Discussion Starter · #12 ·
Talissa,the side effects list give me the feeling to throw up.
My nigthmare still...
 

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Discussion Starter · #13 ·
Talissa,the side effects list give me the feeling to throw up.
My nigthmare still...
 

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Discussion Starter · #16 ·
Apparently,it takes more than just a week to feel any benefits,if there is one.
 

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Discussion Starter · #17 ·
Apparently,it takes more than just a week to feel any benefits,if there is one.
 

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I take paroxetine, for about three years now ans after the first two weeks have had no side effects. Plus it improved my symptoms amazingly. I have had only minor flare-ups in the last three years. So it is not a cure but it certainly can help till there is one. It calms down the CNS and amgdala.
 

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I take paroxetine, for about three years now ans after the first two weeks have had no side effects. Plus it improved my symptoms amazingly. I have had only minor flare-ups in the last three years. So it is not a cure but it certainly can help till there is one. It calms down the CNS and amgdala.
 

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Discussion Starter · #20 ·
Good Soundie,what kind of IBS do you have?What is your dosage.I should masked the symptoms at least.
 
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