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Nippon Rinsho. 2006 Aug;64(8):1452-5. Links [Pathophysiology of irritable bowel syndrome][Article in Japanese]Torii A.Department of Internal Medicine, The Jikei University School of Medicine.Irritable bowel syndrome (IBS) is considered a biopsychosocial disorder resulting from a combination of 3 interacting mechanisms: psychosocial factors, altered motility and transit, which may reflect severity of bowel dysfunction, and increased sensitivity of the intestine or colon. In other words, mechanism in IBS is biopsychosocial disorders; psychosocial factors, altered motility, and heightened sensory function. Understanding the brain-gut axis is the key to the eventual development of effective therapies for IBS.PMID: 16898611