Maybe the pepcid is interacting with something else you are taking and this is affecting a depression? Maybe you were depending on the pepcid to help you out more than it is capable of doing so and this is resulting in depression ? And maybe the pepcid is making you depressed. Or maybe there is a coincidence between the time you began taking pepcid and other things that are going on in your life. It could be a lot of things and I hope someone is able to help you reach an answer. Have you reduced or quit pepcid and found relief?