I just hear too many stories of simplistic diagnoses of IBS when it's something else so I have to ask --- did you have the full battery of tests including upper GI, stool sample, and colonoscopy? Did they exclude everything (ulcers, celiac disease, clostridium difficile, colitis, gluten intolerance, crohn's, cancer, microscopic colitis, etc.)? If so, first be thankful you don't have any of those. If not, get the full battery of tests and also test yourself for lactose intolerance by excluding lactose from your diet. If all the major stuff has been excluded and you are convinced you really do have IBS-D, ask your doctor for a prescription to Motofen. It worked for me INSTANTLY after failing to find success with Pamine, Kombucha, Digestive Advantage, FiberCon, Florastor, Calcium, Xifaxin, Immodium, Lomotil, diet changes, etc. It is my miracle cure, and I wish somebody had suggested it to me five years ago. Good luck!