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I have been on Lotronex since Monday evening and today is the first day I have felt like it's working again. I think that 50% of my problem was that I was worried about it working and the rest was the normal changes in your body when switching medications. (I went form Zofran back to Lotronex). My first two-three days were pretty bad - I lived in the bathroom at work and my commutes were filled with bathroom stops and anxiety.So I am not disappointed by the time it took to "kick" in, I am happy that it did. We should all try to be patient and remember that we got it back and that's the main thing.Happy Holidays to all!
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