Primal Defense did nothing for me and I have found that Culturelle (Lacto GG) is a much more effective probiotic that is available in many health food stores and pharmacies.If you have Crohn's, then I would highly recommend Jini Patel's books, Listen to Your Gut and the IBD Remission Diet. She has Crohn's and has been in remission for years without medication, using mostly diet and natural supplements (aloe, Omega-3, CoenzymeQ 10, etc.) to control symptoms, as well as relaxation techniques.The main reason for trying to get off IBD/Crohn's medications is two-fold: the first being that over time they become less and less effective, the second is because they are mostly steroids and have long-term side effects.While I only have IBS, I have watched a dear friend go through hell with lifelong Crohn's -- surgeries, steroids, etc., along with poor medical advice.Anyway, the books mentioned above offer tremendous help for symptoms of IBS, IBD, and Crohn's.Best of luck and be well.