I am a former pharm rep with GERD/IBS-C/Gastritis and have been on Zegrid for two a years (on and off). In the past, I also tried Prevacid and Nexium. I do not take Zegrid everyday. In fact, I try to take it as little as possible (usually about once a week month). There are two reasons I don't take Zegrid everyday: 1) All PPIs (Zegrid, Prevacid and Nexium) stop working if you take them everyday 2) All PPI cause osteoporosis with long term use.I wanted to know if any long term users have been diagnosed with osteoporosis. I am starting to have problems with arthritis, but have not been diagnosed. I am conccerned and wonder if I could discontinue Zegrid. My IBS-C gets worse when I am completely off Zegrid, but I am starting to get scared with arthritis.