I take Prilosec Twice a day, AM and PM. 40 mg a day. I have Barretts Esophagitis, caused by the long mis diagnosed Acid reflux, and IBS. I have to take it twice a day. I still have the stomach upset, bloating, but I am also on Librax for that, I take that usually twice a day, sometimes 3, on a bad day. It is a antispasmodic,for my IBS, but I've been taking Prilosec now since August, about 2 mnths, and I've noticed I still have the sore throat, raw throat, feels like acid in my throat in the am, and right now, in mid morning, so I'm starting to wonder if the Prilosec is working for me, or the Librax, is lowering the strenth of the LES muscle, and causing the additional reflux. The other PPI'S are very expensive, even with my insurance, I cannot afford them. Prilosec is my only hope, the doc did say I could take up to 80 mg a day if I needed to, hmm, not sure about that.