I tried Primal Defense, and it didn't work for me. I tried bumping up the dosage as my naturopath recommended, and that didn't help either. but my Naturopath did say it works for lots of people, but if it doesn't help with your flora or whatnot there are other things to try such as HMF Forte, which i got on Friday. I just started it so we'll see how it works. Also, like the previous user, I ordered Ibsacol too and I just received it today. I'm very excited.