jh,i have to stay away from all grain and my diet is bare bones organic food.m,i think probiotics are good but for some reason primal defense may bother some people. i don't think it bothered me though.it was interesting because i know this stuff is ACTIVE. it turns my stool dark green, black, brown.and it is not because the base is dark green. i have taken a lot of dark green supplements and nothing has had the kind of effect that this stuff has had.but i took 9 pills per day. expensive!!!!!i am almost positive that very few people will get relief from probiotics alone. much more is needed.