Just thought I would share this -- I was put on Protonix in June, and within 48 hours, my GERD was completely under control. I ended up going off it to see what would happen, and it eventually came back. Fortunately, I do not have a terrible case of it, but I know I will as I get older. My father's side of the family has so much history with it. I choose not to be on it, but that's not because it doesn't do its job or has a lot (or any) of side effects. I hope this can help some of you.