I was taking a large dose of Prozac (90mg. per day) for seven years when my bowels suddenly stopped working. That was two years ago and nothing except Dulcolax (in increasingly larger doses) has worked to relieve the constipation since. I have been diagnosed as having "colonoc inertia". I have only seen one reference to high doses of Prozac as a possible cause of my condition and none of the doctors I have asked have any knowledge of a possible connection. Has anyone else had this happen while taking Prozac or has anyone heard of it being a possible cause of chronic constipation?