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No info on which is best, but the info about plenty of water is very correct You definitely need to take with lots of water. Too much fiber without enough water can cause a blockage. I think the avoiding taking medicine at the same time makes sense, just in case it blocks the absorbtion.Don't know if it would do anything for concurrently eaten fat. I know it binds bile acids but don't know about fat (it is used to lower cholesterol because once the bile is bound it is not recycled and you make new bile from cholesterol in the blood)
 
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