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Cytokine gene polymorphisms in irritable bowel syndrome in Indian population--a pilot case control study.

Trop Gastroenterol. 2010 Jan-Mar;31(1):30-3

Authors: Santhosh S, Dutta AK, Samuel P, Joseph AJ, Ashok Kumar J, Kurian G

AIM: This study aimed at evaluating the single nucleotide polymorphisms (SNPs) in five cytokine genes regulating inflammation at altogether 8 different loci and compared their frequencies in patients with Irritable bowel syndrome (IBS) versus healthy age and sex matched controls. METHODS: Peripheral blood was collected for DNA cytokine analysis from 23 patients with lBS and 20 healthy controls. The cytokine SNPs studied include TNF-alpha (-308G/A), TGF-alpha1 (codon10T/C, codon25G/C), IL-6 promoter (-1082A/G; -819T/C; -592A/C), IL-6 promoter (-174G/C), and IFN-alpha (+874T/A). RESULTS: There was a significant difference between a SNP in IL-b (-592A/C) among cases and controls. There was also a trend to significance as regards to IL-6 promoter (-174G/C). Frequencies of other SNPs were not significantly different between the two groups. CONCLUSION: This pilot study shows that there are polymorphism differences in cytokine genes between patients with lBS and healthy controls from India.

PMID: 20860222 [PubMed - in process]

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