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Effect of Meal Ingestion on Ileocolonic and Colonic Transit in Health and Irritable Bowel Syndrome.

Dig Dis Sci. 2009 Dec 1;

Authors: Deiteren A, Camilleri M, Burton D, McKinzie S, Rao A, Zinsmeister AR

BACKGROUND: Postprandial symptoms in irritable bowel syndrome (IBS) have been associated with increased bowel contractility. AIM: To compare ileocolonic and colonic responses to feeding in health and IBS. METHODS: We prospectively analyzed data from separate research trials in 122 IBS patients and 41 healthy volunteers. Ileocolonic transit (ICT) was evaluated before (colonic filling [CF]3h) and immediately after (CF4h) a standard lunch at 3 h 45 min, and 2 h thereafter. The colonic geometric center (GC) was calculated 2 h (GC6h) after lunch ingested at 4 h (GC4h) and directly after (GC8h) a standard dinner ingested at 7 h 45 min. RESULTS: ICT immediately after eating was higher in IBS diarrhea predominant (IBS-D) patients than in the healthy cohort (23.1 +/- 2.4 vs. 17.5 +/- 2.8%, P = 0.059). ICT 2 h after lunch was similar between groups (P = 0.55). There was significant overall group differences in colonic transit 2 h post-lunch (P = 0.045), particularly in the IBS constipation predominant (IBS-C; GC6-GC4, Delta0.29 +/- 0.08) patients versus healthy volunteers (Delta0.56 +/- 0.12 GC units). CONCLUSIONS: After feeding, ICT is increased in IBS-D, whereas colonic transit is blunted in IBS-C.

PMID: 19949866 [PubMed - as supplied by publisher]

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