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Enantioselective Synthesis of SSR 241586 by Using an Organo-Catalyzed Henry Reaction.

Org Lett. 2010 Jul 28;

Authors: Cochi A, Métro TX, Pardo DG, Cossy J

An organo-catalyzed Henry reaction, applied to an alpha-keto ester, has allowed the enantioselective synthesis of SSR 241586, a 2,2-disubstituted morpholine active in the treatment of schizophrenia and irritable bowel syndrome (IBS).

PMID: 20666443 [PubMed - as supplied by publisher]

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