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Epidemiology of functional dyspepsia and subgroups in the Italian general population: an endoscopic study.

Gastroenterology. 2010 Jan 11;

Authors: Zagari RM, Law GR, Fuccio L, Cennamo V, Gilthorpe MS, Forman D, Bazzoli F

BACKGROUND & AIMS:: Population-based endoscopic studies are needed to assess the epidemiology of functional dyspepsia (FD) and the newly suggested subgroups of meal-related symptoms and epigastric pain. We evaluated the prevalence of, and risk factors for, FD and subgroups in the Italian general population. METHODS:: This is a cross-sectional population-based study. 1533 inhabitants of two villages, recruited as part of the Multicentre Italian Study on Cholelithiasis, were invited to undergo symptoms evaluation using a validated questionnaire, esophagogastroduodenoscopy and (13)C-urea breath test; 1033 subjects (67.4%) took part. RESULTS:: Of the 1033 subjects, 156 (15.1%, 95% CI: 12.9-17.3) had dyspepsia, and of these 114 (11%, 95%CI: 9.2-12.9) had FD. Of the 114 subjects with FD, 77 (67.5%) had meal-related symptoms (postprandial fullness and/or early satiation) and 55 (48.2%) epigastric pain. Only 18 (15.8%) subjects suffered from both meal-related symptoms and epigastric pain; this was fewer than expected by chance alone (p<0.001). Unemployment (OR 5.80, 95%CI: 1.56-21.60), divorce (OR 2.76, 95%CI: 1.10-6.91), smoking (OR 1.74, 95%CI: 1.11-2.70) and IBS (OR 3.38, 95%CI: 1.85-6.19) were significantly associated with FD. Unemployment, divorce and IBS were associated with both meal-related symptoms and epigastric pain, while smoking was associated with meal-related symptoms, but not with epigastric pain. CONCLUSIONS:: We estimated that FD is present in 11% of the Italian general population. Unemployment and divorce seem to increase the risk of FD, and smoking seems to be associated with meal-related symptoms. Two distinct subgroups of FD, as suggested by Rome III, seem to exist in the general population.

PMID: 20074574 [PubMed - as supplied by publisher]

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