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Gastrointestinal Microbiota in Irritable Bowel Syndrome: Present State and Perspectives.

Microbiology. 2010 Aug 12;

Authors: Salonen A, de Vos WM, Palva A

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that has been associated with aberrant microbiota. This review focuses on the recent molecular insight generated by analyzing the intestinal microbiota in subjects suffering from IBS. Special emphasis is given to studies that compare and contrast the microbiota of healthy subjects with that of IBS patients classified into different subgroups based on their predominant bowel pattern defined by the Rome criteria. The current data available from a limited amount of patients does not reveal pronounced and reproducible IBS-related deviations of entire phylogenetic or functional microbial groups, but rather support the concept that IBS-patients have alterations in the proportional share of commensals with interrelated changes in the metabolic output and overall microbial ecology. The lack of apparent taxonomic microbiota similarities in IBS patients may partially arise from the fact that the applied molecular methods, the nature and location of IBS subjects, and the statistical power of the studies have varied considerably. Most recent advances, especially the finding that several uncharacterized phylotypes show nonrandom segregation between healthy and IBS subjects indicate the possibility for discovering bacteria specific for IBS. Moreover, tools are being developed for the functional analysis of the relationship between the intestinal microbiota and IBS. These approaches may be instrumental in the evaluation of the ecological dysbiosis hypothesis in the gut ecosystem. Finally, we discuss the future outlook of research avenues and candidate microbial biomarkers that may eventually be used in IBS diagnosis.

PMID: 20705664 [PubMed - as supplied by publisher]

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