Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans.
Blood. 2010 Jun 10;
Authors: Guo PF, Du MR, Wu HX, Lin Y, Jin LP, Li DJ
Thymic stromal lymphopoietins (TSLP) play critical roles in dendritic cell-mediated immune responses. In this study we found that human trophoblasts and decidual epithelial cells in maternal-fetal interface of early placentas express TSLP mRNA and protein, but only trophoblast cells secret soluble TSLP. Human decidual CD1c(+) DCs (dDCs) highly express the functional TSLP receptor complex TSLPR ad IL-7Ralpha. Recombinant human TSLP activates CD1C(+) decidual DCs and peripheral Mo-DCs with increased co-stimulatory molecules, major histocompatibility complex (MHC) class II, and OX-40L. Human TSLP or supernatants from human trophoblasts specifically stimulate dDCs to highly produce IL-10 and T(H)2-attracting chemokine CCL-17. The TSLP-activated dDCs prime decidual CD4(+) T cells for T(H)2 cell differentiation, involved in maternal-fetal immuno-tolerance. Interestingly, the protein expression of TSLP in normal pregnancy with significant T(H)2 bias is much higher than that of miscarriage showing TH1 bias at the maternal-fetal interface. Therefore, human trophoblasts may contribute to maternal-fetal tolerance by instructing dDCs to induce regulatory T(H)2 bias in human early pregnancy via TSLP.
PMID: 20538796 [PubMed - as supplied by publisher]
View the full article