Varian, IBS is a funtional disorder and motility is part of the picture.Lotronex was taken off the market.For accurate information from the top center on IBS that will explain all this to you.UNC Center for Functional GI & Motility DisordersThere is a lot of information here. http://www.med.unc.edu/medicine/fgidc/ There is a link there that explains some of the different conditions. http://www.med.unc.edu/medicine/fgidc/motility.htm ------------------Moderator of the Cognitive Behavioral Therapy, Anxiety and Hypnotherapy forumI work with Mike and the IBS Audio Program. www.ibshealth.com www.ibsaudioprogram.com