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Both of those act similarly as "sponges" in the digestive tract. There have been lots of success stories withthem. If you have started on the Questran, you might as well continue that to see if it is effective for you. There was a posting re Calcium without Magnesium that suggested some long term problems in your joints from not using both together. Since the Caltrate in question is without Magnesium, and since your doctor is onside with the Questran, that would be another good reason to stick with it.Mark