I've been diagnosed with IBS w/D after several test came negative and my GI put me on Lotronex . This gave me more gas, bloating and cramps so he added Robinul Forte and decreased the dose of Lotronex to 1/2 mg once a day. The only change I noticed was that my BM became semi formed and less frequent, but I'm still bloated and esp. at night my stomach churns all night long,I feel lot of pressure until I have BM in the morning.I was hoping that Lotronex will take care of these symptoms, but it seems they are worse.I've been taking it only for one week and I wonder if this normal reaction ... Does anyone have similar experience or advise?