Hi, I'm new to this group & am desperate to find help. I've had IBS-D for about 20 years, but for the past six months it has made my life miserable. I, too, have seen numerous doctors and specialists over this time who just keep throwing different ideas out there. Worse yet, one physician made no recommendations or prescriptions at all & did not respond to my repeated pleas for help. I'm afraid to go to work or to go out socially & have isolated myself completely from work functions. I've missed more than my maximum allowed time from work, as well. Today, I'm sitting out of the office Thanksgiving potluck, frequently I miss the office lunches. This is not a condition you can share with others, so it just seems I'm being anti-social. I have tried diet restrictions, supplements, prescriptions. . . & like you were, I find myself living on Imodium presently. However, this doesn't solve the feeling of incomplete evacuation or the cramping. I've lost 15 lbs over the last six months & quite frankly can't afford to lose any more. But I'm afraid to eat unless I'm in my own home & have nowhere to go for the next few hours. I'm curious what other natural &/or prescription treatments you had tried before landing on this current regimen? And, are you consuming all of these at one time of day: morning, evening...? Thanks so much! I'm glad to have found a community of people with whom to commiserate.