[eric]

FYI:There is some important info in this. http://www.macmcm.com/pcp/pcp2000_01.htm "Modulatory factors. Finally, the CNS processing of sensory experience may be simultaneously modulated by two parallel pathways: memory-based modulation and stress- or arousal-induced modulation. The posterior parietal cortex, or sensory association cortex, forms a network with the hippocampus and the amygdala (the brain's memory centers) as well as with the lateral prefrontal cortex. Somatic pain studies have shown that, in response to a stimulus, the recall of a similar past event, along with subsequent interpretation of this memory in the lateral prefrontal cortex, plays a major role in the threat appraisal of a sensory experience. The second modulatory effect is the stress- or arousal-induced response. The pontine locus ceruleus is activated in response to potentially threatening experiences. This region then projects to nearly all other regions of the brain that receive visceral input, causing secretions of norepinephrine and arousal of these sections of the brain. When the secretion of norepinephrine is excessive, these target regions are inhibited. It is of interest that descending projections from the locus coeruleus complex to the sacral spinal cord appear to play a major role in the modulation of distal colonic motor and secretory function."

 

[KerryW]

Hmmm, interesting Eric. The conclusion they come up with sounds like to me that they think that is "all in our heads".

gosh, what a nice thought.Thanks for some informative reading and making my head spin!! lol.No seriously, thank you, maybe there is something that they can find to help us all.Ciao

 

[KerryW]

Hmmm, interesting Eric. The conclusion they come up with sounds like to me that they think that is "all in our heads".

gosh, what a nice thought.Thanks for some informative reading and making my head spin!! lol.No seriously, thank you, maybe there is something that they can find to help us all.Ciao

 

[eric]

Kerry, its not all in our heads, but the brain and the gut are both operative in IBS, which is very important. Its the regulation of chemicals that are out of whack between the gut brain and the main brain.Here is the pet scan images of one study and this was 97, since then they have taken more images and they know more about how this is all working and some of what is doing what or not doing what. http://webpotential.com/uploadpic/

 

[eric]

Kerry, its not all in our heads, but the brain and the gut are both operative in IBS, which is very important. Its the regulation of chemicals that are out of whack between the gut brain and the main brain.Here is the pet scan images of one study and this was 97, since then they have taken more images and they know more about how this is all working and some of what is doing what or not doing what. http://webpotential.com/uploadpic/

 

[Mike NoLomotil]

KERRY:I also recommend strongly, since the thread is about New Perspectives, that you also read the following thread in its entirety so as to muse over the broader perspective of the physiology of different IBS subpopulations, and how the central nervous system, peripheral nervous system, immune system, endocrine system and excorine system are fully integrated, codependent, and hoiw separate investigators not collaborating are finding complementary information to each others IBS studies.This truly reflects the range of new perspectives on IBS in the last several years when the finidngs are integrated. Putting all the info together yeilds a better understanding than either set of finidngs reviewed in a vacuum from the other. http://www.ibsgroup.org/ubb/ultimatebb.php...ic&f=1&t=024457 Eat well. Think well. Be well.MNL

 

[Mike NoLomotil]

KERRY:I also recommend strongly, since the thread is about New Perspectives, that you also read the following thread in its entirety so as to muse over the broader perspective of the physiology of different IBS subpopulations, and how the central nervous system, peripheral nervous system, immune system, endocrine system and excorine system are fully integrated, codependent, and hoiw separate investigators not collaborating are finding complementary information to each others IBS studies.This truly reflects the range of new perspectives on IBS in the last several years when the finidngs are integrated. Putting all the info together yeilds a better understanding than either set of finidngs reviewed in a vacuum from the other. http://www.ibsgroup.org/ubb/ultimatebb.php...ic&f=1&t=024457 Eat well. Think well. Be well.MNL