Hi Mary,No I have not tried Zoloft and since it is an SSRI (selective serotonin reuptake inhibitor) I will not try it. This is due to my extreme sensitivity to SSRI's which I found out the hard way when I was taking Lexapro (also an SSRI). Zoloft carries the Discontinuation Syndrome warning that all SSRI's are required to carry. Those of us who have suffered from SSRI Discontinuation Syndrome know that this is just a nice way of saying you are undergoing withdrawal side effects. But the manufacturers claim that SSRI's are not addictive, hence you cannot have withdrawal side effects. So, regardless of what you call it, getting off this med was horrifyingly difficult for me. SSRI's also make you more prone to GI bleeding especially if you take any NSAIDS.Sorry I went off on a bit of a rant. I don't mean to discourage you, if this is a medication you would like to try. I just cannot give you any positives concerning SSRIs.As for why your doc gave you Savella, well in my experience docs have a strong desire to fix things (make their patients better) and since that is pretty hard with IBS, they tend to just throw things at it, hoping something will work. Plus Pharma's really push their new meds on the docs. How else will the pharma's make any money.I rather doubt that any of the TCA's, SSRI's, or SNRI's are actually going to help your constipation, that is not what they were designed to do (unless you find one that has the side effect of diarrhea.) But they may help if you have pain associated with your IBS. I suffer from severe abdominal pain which the TCA doxepin helps significantly. But I still suffer from contipation on a daily basis. But it is much easier to tolerate the constipation when I'm not also in pain.Good Luck,Zanne