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serotonin levels, Mao levels among the anxious men of India with IBS-D.Correlation of serotonin and monoamine oxidase levels with anxiety level in diarrhea-predominant irritable bowel syndrome.Singh RK, Pandey HP, Singh RH.Department of Biochemistry, Faculty of Science, Institute of Medical Sciences, BHU, Varanasi 221 005. rakeshbhu###yahoo.comBACKGROUND: Irritable bowel syndrome is generally considered to have a psychogenic component in its physiopathology. AIM: To study the role of serotonin 5-hydroxytryptamine; 5-HT, monoamine oxidase MAO and anxiety, and to elucidate the relationship between these in patients with diarrhea-predominant IBS. METHODS: 5-HT and MAO activity and anxiety levels were studied in 20 healthy volunteers aged 18-25 years; all men and 57 patients with diarrhea-predominant IBS 30-60 years; all men. RESULTS: The concentrations of 5-HT and MAO , and the anxiety level score were significantly higher in patients than in healthy volunteers , 6.4 and 3.4 , respectively. These parameters correlated with each other in both patients and volunteers. CONCLUSIONS: Elevated 5-HT and MAO activity and anxiety may play a role in patients with diarrhea-predominant IBS.tom
 
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