Most Syndromes end up as diseases or multiple diseases once science finds the underlying physical causal basis for the symptoms. This can take a long time, and during the "syndrome phase" the symptoms are often considered, usually erroneously in retrospect, as "functional". This is sort of like the lost keys. They exist, and are not really lost, they just have not been found yet. So ditto for IBS. As more and more "causal" bases for the symptom sets are revealed, over time the population which inhabits the "IBS Symptom Based Diagnosis" population will dwindle. It is sort of like what happened with COPD before the whole distinc etiologies of chtronic bromchitis, pan and centra-aciner emphysema, and reversible airways obstruction (asthma) were wholly understood. Or IRDS of the neonate which was idiopathic only becasue we lackd the technology to isolate the cause. So when the cause is isolated its not idiopathic anymore. End of mystery. For "IBS" not yet, but getting closer all the time.MNL