Has anyone tried Sinequan? According the the IBS Self Help Group Med Listing, it is an anti-cholinergic which lessens gut activity. I looked it up; it is an anti-depressant. I have been trying for many months to go the natural route, but I am so tried of waking up in pain, etc. IBS is running (ruining?) my life. Another thing I am considering is the Librax.My problem is mostly in the AM (loose,) as soon as I get up and for a few hours afterwards, but I have pain/discomfort thru the day. I have been on the Caltrate Plus for 11 days, but so far no great improvement... (I'm still hoping and praying, though!)Any ideas/help much appreciated!!!BTW, I took one Elavil just a few days before the IBS began (for nerve pain, plus I was extremely stressed out.) The day after the D began, I developed tinnitus (ringing in my ears.) I'm not sure how or if this is all connected. The tinnitus (still have it) could be from the nerve damage, I have been told. Anyway, what I am trying (sorry so long) to say is that I am soooo afraid of side effects.OK, I have been going on and on, but I just want to add this: Having you guys to talk to means a lot to me. Were it not for the "miracle" of the internet, I would feel all alone with this. I have gotten more help and hope here than from all the docs and tests. So much kindness and goodwill. THANK YOU & GOD BLESS YOU ALL!!!