Hi...it's been a while since I've been back on here...but felt a need to return. I've been dealing with IBS-D for MANY years...but I feel like I'm at the end of my rope. I know there are people who are much worse than me, with more "serious" problems, but this IBS-D is really taking its toll. I had to go out of state this past weekend for a funeral. Usually when I travel, I have to take Immodium and take more than is suggested. Well, I took it, but ended up having D anyway the next morning (usually if I take the "extra" Immodium, it still works for a few days). So I took some more before the funeral. Then coming home that same day, on the second day of this trip, we had to stop by my aunt's house, and the D hit again (even after taking Immodium 2 days in a row! I started shaking all over...(I also suffer from anxiety and panic attacks)..and cried so hard...and told my husband that I'm so tired....tired of dealing with this. Sometimes, it's all I can do to go to the mall 20 mins from my house. I had gotten "better" a while back, but this year has been really hard emotionally and I guess that's part of the problem. I have another trip, weekend, planned for in Oct...but I'm scared to go now...thinking the Immodium won't work. I also take Xanax (usually 1/2 - 1 whole .5 mg several times a day). I also take Levsinex for my stomach...and Tenormin for the Mitral Valve Prolapse. I'm sorry that this is so long...it's just that it gets so depressing...my dr had mentioned to take St.John's Wort for the mild depression, but I haven't. I just don't want to get as bad as I used to be, where I became agoraphobic...but it's getting harder again to go places. I'm only 45, but I "feel" so much older...ya know?