quote:Now my questions are what are your thoughts on the pain ? If that pain is brought about by a suddencontraction of the muscles in the gut (a 'spasm') then do you not think that a spasm IS (or should be made) a symptom of IBS (assuming that definate physical recording of the spasm can be made).
The definition of IBS is based on the fact that enough patients are reporting similar symptoms that the experts have felt (presumably while enjoying the sights and food in Rome
constitute a single entity they term IBS.The goal is here is to identify a specfic disease state so that doctors in practice can diagnose IBS and follow a specific protocol for treatment.The reason that symptoms are used is largely because there is no one physiological correlate that is present in everyone who reports these symptoms. If it were found to be the case that every IBS subject had a particular abnormal physiological correlate, such as spasms, I think the experts would incorporate this into Rome. At that point, IBS is technically no longer is a syndrome but a disease.In actuality, the Rome criteria as it stands almost certainly includes persons who have something that will ultimately be the "true" IBS and others who have something that is not IBS.Currently, many, but not all, IBS subjects who have been tested have visceral hypersensitivity, which is measured using a barostat in the rectum. These IBS subjects feel pain at slight distension of the barostat while healthy people do not.So it is a possibility that the next "version" of Rome: Rome 3.0 will formally name a specific irritable bowel disease.
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o you feel there are other reasons for the pain often associated with an IBS 'diagnosis' ?
Not sure what you mean, the cause of the pain being the result of something other than visceral hypersensitivity? If so, I tend to think that the pain is mainly due to visceral hypersensitivity. However, it is conceivable that a particular person's disease could be affecting motility as well and the two be present simultaneously.
quote:"Once something like "spasms", whatever that really is, is detected, the diagnosis should be changed.", do you have any suggestions as to what that diagnosis should be changed to ?
Currently, our means of studying gut motility is pretty pathetic. The intestine is about 30 feet long but most motility testing looks at just the first and last two feet of that. In addtion, most people with IBS symptoms do not even get these tests. Even with the limited testing, there are a number of specific motily disordersdiffuse esophageal spasmachalasiaGERDgastroparesispseudo-obstructionslow-transit constipationpelvic floor dysfunctionHirschprung's disease