2 apt observations.... _____________________________________"This may berelated to the fact that whatever mechanisms cause the hypersensitivity in the coloncan also have the same effect on other parts of the body." ____________________________________Ineed...the leukotrienes, cytokines, prostaglandins and other proinflammatory mediators which may be released from the variosu classes of immunocytes when provoked are not limited in their effects to those which are localized in the small bowel (where the primary reactions are observed)...rather since they are released into the systemic circulation as well (as the immune system has designed them to be in response to pathogens) they afect other bodily organ systems in specific untoward ways.In addition to the other symptoms mentioned, another common one is "urinary frequency", dysmenorrhea, and "CNS activation" in its grossest form manifesting itself as ADD/Hyperactivity in children....sensations of feverishness, hot flashes, sweatiness, claminess, dizziness, "Fog-brain" ad nauseum in adults.This is covered in detail in these bboks by experts on the subject:"FOOD ALLERGIES AND FOOD INTOLERANCE: THE COMPLETE GUIDE TO THEIR IDENTIFICTION AND TREATMENT", Professor Jonathan Brostoff , M.D.. Allergy, Immunology and Environmental Medicine, Kings' College, London
http://www.amazon.com/exec/obidos/ASIN/089...6487508-3420903 FOOD ALLERGY AND INTOLERANCE, Professor Jonathan Brostoff, MD, Stephen Challacombe, MD (NEW 2002)
http://www.amazon.com/exec/obidos/ASIN/070...product-details ________________________________"Mike--perhaps that explains why the "consequences and repercussions" are minimized when a "flare-up" is not in session." ________________________________Yep that is a good observation. The effects are additive and cumulative. If , for example, the bowel has been "antigen free" for a period of time and the patient ingests an offending food which results in a mild response, it may be subclinical....not enough for the patient o perceive any symptoms.If, on the other hand, the person has recently consumed something to which they are moderately to severely reactive and are experiencing some symptoms then ingests that substance to which they are mildly reactive, even though by itself and at that dose the reaction might be so modest as to be subclinical, the additive effect of the second reaction...it may even be potentiative...will result in noticeably worse symptoms under these circumstances.I can cite personal experience as an example. Previously, when I consumed Italian food almost daily for umpteen years, I lost tolerance to wheat, tomato, basil, oregani, garlic, onion etc.After a period of 2 years of total avoidance of those (and other) reactive foods, I regained tolerance to modest amounts of wheat.After an added year or two of no ingestion of tomato sauce with oregano, basil, garlic onion etc.(good old spaghetti sauce) I regained tolerance to modest combined doses.In other words I can now go to Sbarro once a week (their sauce is very mild) and consume a big bowl of speghetti and meatballs with 2 garlic breadtsicks! And remain asymptomatic! Or consume 2 slices of pizza...not a twinge.To me this is better thn waking up one day and finding MrsNL has miraculouly become 24 years old again!
Well, almost....
MNL