I wouldn't recommend it. My doctor took me from Zoloft to Paxil without weaning me and I have suffered a soapy, metallic, bitter taste in my mouth since. Doesn't sound related does it? Well, might not be...all I know is that's when the taste problem started and I never have gotten rid of it (2 years later). I just went off my most recent anti-depressant and the taste problem is better. However, I still have the taste problem and fear it might now also come from the Asacol I take for ulcerative colitis. I'm sure some of it may be related to acid reflux as well. Some medications relax the esphogeal sp? sphincter...I'm wondering if that's what anti-depressants did to me (irreversible?). Not saying this would happen to anyone else in the world, just saying to be cautious. Who knows what harm SSRIs can do to some people. Works wonders for others. I would LOVE to be able to take them. Can't, they make this taste unbearable!!! Anyone else with a bitter taste in thier mouth that would like to share their stories (success and discomfort), please post.