Hi-I just started taking Lotronex yesterday and I don't feel so good. Not that I felt good before ... I'm wondering if anyone taking Lotronex felt nauseous and anxious at first? If so, how long did it last?I took my first dose yesterday at work and felt nauseous and anxious. I have Xanax for the anxiety, but nauseous is just - YUCK! This morning I feel the same way but worse. I'm having loose stools, but I'm used to that.I've had IBS for almost 5 years - tried various meds: Elavil, Celexa, Questran, Desipramine, Levsin, Librax, and lots of "alternatives" like fiber, peppermint oil, etc. I was really sick with it at first, even had to quit working for awhile, but by the beginning of 2009, I had it pretty much under control. Then I hurt my back. After physical therapy didn't help, this horrible pain management doctor decided I had fibromyalgia and put me on 2700 mgs of Neurontin in May. The Neurontin actually helped my stomach, but made my anxiety increasingly worse, and if I forgot to take it, I had horrible panic attacks and couldn't keep any food down (or up). Then at the end of August I went to Las Vegas for my 10th wedding anniversary and got food poisoning (I think - at this point with my crazy digestive system who knows). Turns out I didnt' need the Neurontin - I needed a good chiropractor. Started seeing one in September and my back was almost instantly better. Getting off the Neurontin was the worst experience ever. I spent days and weeks so sick all I could do is try and lay as still as possible when I wasn't running to the bathroom with horrible D. I couldn't eat and had horrible panic attacks. I've barely kept my job I've missed so much work. The %^&% doctor that put me on the Neurontin said it couldn't be withdrawal from the drug and actually tried to get me to take more. Good news tho - I took my last dose of Neurontin a week ago. NEVER AGAIN!In October I went to my PCP and she refilled the Librax (which helps a little bit) and got me a referral to a GI. He tried Desipramine first (helped a little bit) and now we're trying Lotronex. I haven't eaten anything but white bread, rice, potatoes & bananas for months, and I've lost 15 pounds. Last night I tried to eat "real food" - Amy's organic mac & cheese - which went ok last night, but not so much this morning. I know people with IBS are suppposed to avoid dairy, but its never bothered me before. Just to make things interesting, later this morning I have to go get an emergency crown on my tooth. Then tomorrow I'm supposed to travel to a wedding - the hotel is 4 1/2 hours away and the actual wedding is 1/2 hour outside of town in the middle of nowhere at someone's home. 2 bathrooms for over 100 people. Sorry for the ramble - its just so nice to "talk" to people that actually understand. This board has helped me keep my sanity the last couple of months, even though I haven't posted. Just by writing this, I think I've realized I'm expecting a bit much too soon. But I would like to know if the nausea/anxiety is going to go away. Thanks so much for "listening"!