i started on lotronex about three weeks ago. after reaching rock bottome with my ibs- i regained some hope. i have two comments/questions:1. lotornex works for me when i am alone, but as soon as i am with others and become anxious (where's the bathroom!?) it no longer works. i have learned that ANXIETY is huge with IBS. has anyone taken anything for that? or have any suggestions.2. with lotronex i swim to have less D but more cramping. i usually have to use the restroom when i feel pain- but it is no longer D which is good, but not perfect yet. anyone else feel more pain?