I don't have a serious daily diarrhea problem. I decided to take one lotronex on the day before I had a two hour eye surgery so I wouldn't have a diarrhea problem. I stayed away from foods that give me diarrhea to keep me safe from diarrhea. My surgery was on Wed. July 7th. I didn't have a b.m. until Friday. I still felt like I needed to eliminate but I couldn't. A neighbor brought me an exotic dish to eat for lunch on Friday and I ate part of it and then on Saturday I finished it. Now..... here is the strange part of my experience..... I was watching t.v. and all of a suddened I felt I needed to run to the bathroom. Meanwhile... I felt like I was bleeding from my vagina and thought maybe I was having a period. I could feel lots of fluids coming out of my vagina.... But when I sat on the toilet I noticed a runny yellow substance of feces on my vagina. As I was having the diarrhea..... I also evacuated the firm stool that had been created by the lotronex that I had taken previously. I was totally taken by surprise that I could have diarrhea and a normal stool at the same time because that has never happened to me before while taking Lotronex. I took a shower and washed myself really good and took another Lotronex and then later on decided to take pepto bismol to clean out the bacteria from my stomach. There are two possible things that could have caused my problem. The exotic food and all the drugs I had to take after my eye surgery. I think it was caused by both. I have come to the conclusion that I really don't have security with just taking Lotronex..... I have chosen to wear "Depends" while I am having this medical problem. I don't want to have an uncontrolable experience of having diarrhea in public or while sleeping in bed. I am okay now but it was real scary if this had happened to me in a public place. Yikes!!