I have suffered from IBS-D for several years and have tried all kinds of treatments. I've watched my diet, taken meds (Bentyl, Immodiumetc.) with no success. I was so excited about lotronex and thought that would be my answer. Sadly, I had a terrible reaction to it, cramps (which I expected from reading the posts here) but then I on the third day of taking it I got such severe diarrhea that it caused bleeding from the anus. I decided to try another regimen. I startedtaking one Lomotil after breakfast and thena heaping tablespoon of Metamucil in the afternoon. Wow. It worked like magic. I have had only one or two BMs a day and they were not loose at all. No cramps but a little gas. (small price to pay) This has been going on for a month! I just can't believe it yet.I am leaving for a ten day trip to New York on Monday armed with my Lomotil, Metamucil and Immodium. Wish me luck!!