I have taken prozac in the past. Then I hardly had an episode of IBS and it completely removed it from the pic for me for 3 years. Now, that I have had a major crisis for a month and a half -- most severe in my life -- I am on PAXIL (12.5 mg). It does not change my mood at all. I am not too sure if it is helping me with a D that now became C. But overall it is some help, I am sure. The drug does not prevent you from crying when you are sad, for example. You remain human - sort of speak, and nostalgic if it is the case. You do not develop into a new person, just perhaps a less extreme version of yourself (in the anxiety sense).In the past I have taken Zolof for depression (no IBS then). I am not sure which of these drugs is the best, but they all had no side effects for me, and never really altered my mood in significant ways. I recommend them.