I wouldn't take the probiotic with the Xifaxan. I have been on Xifaxan for 7 days now, and I stopped taking any homemade yogurt and probiotics. Probiotics are just adding a bacteria to your GI tract, the Xifaxan is trying to kill everything down there. I don't want anything to interfere with the $200+ I'm spending for 10 days of Xifaxan.Yeast infections are VERY unlikely with Xifaxan, at least according to Pimmental and other info on the web. Xifaxan stays in the GI tract almost exclusively. Other antibiotics get in the blood stream, which can then lead to yeast infections and so on.