I am a long term sufferer of IBS-D and had pretty much got to the stage where I realized that nothing more could be done to help me - I had tried pretty much everything - change diet, more exercise, more sleep, immodium (in the am), calcium, peppermint, cut out caffeine/chocolate, anti-anxiety drugs (effexor) - with no positive results. The only thing I hadnt tried was Lotronex (I am male and therefore wasnt sure of the impact of this drug). Numerous trips to the Gastroenterologist with the same response - you have IBS and there is no known cure and everyone is different! Anyway, just by coindicence I decided to try taking immodium in the evening after dinner before going to sleep. I started this a month ago and I have been completely IBS-free ever since - utterly unbelievable - this was literally an overnight "silver bullet" for me Anyway - I know everyone is different, but just thought I would share my experience with you guys Chris