I've had IBS-D for as long as I can remember. I was reading the bulletin board and saw one from LNAPE regarding taking Caltrate 600 Plus, so after going to two Gastroenterologists and a Naturopath, none which helped with their drugs and natural methods, I tried Caltrate 600 Plus and within two weeks my IBS-D was better. My husband and I just took an 18 day motorhome trip and thanks to LNAPE and Caltrate 600 Plus, I had a wonderful trip and only had about two - three IBS-D issues and that was because I ate something I shouldn't have. So even if you're taking Immodium and/or Pepto Bismol, I'm sure if you try Caltrate 600 Plus you'll find some much needed relief. I bought the chewable ones in the white and orange box, and they taste really good. I wish you all luck, and I feel so very lucky because of LNAPE.