my daughter can't take lotronex and is pretty much an invalid from severe pain, diarrhea and fatigue. her doctor prescribed tincture of opium. Do opiates work the same way as lotronex, that is do they affect seratonin Or does opium just slow everything down? She hasn't been given much guidance on how to take it. (except be careful not to take too much) If anyone knows, is it better to divide it up into several times a day? Better at night or morning? And is tincture of opium a pain killer too? (seems like it would be) Also does anyone find that the opium itself is hard on the stomach? Also for those of you who've taken it long term, have there been side effects? Thanks for any info.